Licorice root extract is often used to relieve symptoms of indigestion, such as acid reflux, upset stomach, and heartburn.

In a 30-day study in 50 adults with indigestion, taking a 75-mg licorice capsule twice daily resulted in significant improvements in symptoms, compared with a placebo .

Licorice root extract may also alleviate symptoms of gastroesophageal reflux disease (GERD), including acid reflux and heartburn.

In an 8-week study in 58 adults with GERD, a low dose of glycyrrhetinic acid in combination with standard treatment resulted in significant improvements in symptoms .

Another study in 58 adults with GERD noted that the daily use of licorice root was more effective at reducing symptoms over a 2-year period than commonly used antacids .